CWRUmedicine’s Inflammatory Bowel Disease Research Update

Investigators, led by Fabio Cominelli, M.D., Ph.D., formed an integrated team to explore multiple aspects of intestinal inflammation utilizing clinical resources as well as animal models of Crohn’s disease and ulcerative colitis. Some of the topics under investigation include intestinal cytokine regulation, immune-nonimmune cell interactions, extracellular matrix biology, tolerance to indigenous intestinal flora, and state-of-the-art gene expression profiling by DNA microaray technology. In collaboration with the Division of Pediatric Gastroenterology and Nutrition, these investigators have been previously awarded by the National Institutes of Health a large five-year program project grant to study pediatric inflammatory bowel disease, the only such program in the country during that period. Basic research is complemented by a variety of clinical and translational studies. These include investigation of inflammatory bowel disease in minority populations, intestinal permeability in Crohn’s disease families, and an active program of clinical trials with state-of-the-art immunomodulators and biologicals.

Learn more at CWRUmedicine.org

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