Archive for the ‘Research’ Category

Research Day :: Photo Gallery

June 2, 2010

Research Day :: May 7, 2010

Congratulations to everyone who participated in the Department of Medicine 2010 Research Day. The event had a tremendous turnout of faculty and young investigators. We are very proud of the research you are producing.

Check out the pictures from this CWRUmedicine event …

Good Morning America visits new heart imaging device in Cleveland

May 27, 2010

Dr. Marco Costa found a second blocked artery in Mack Bailey’s heart — and demonstrated to a Good Morning America audience the first vascular-imaging technology based on optical coherence tomography (OCT) — at the same time Thursday.

Costa is an interventional cardiologist and director of the cardiovascular research institute at University Hospitals Case Medical Center in Cleveland, Ohio. Bailey is a 60-year-old Clevelander with had a heart attack and is being treated by Costa.

Both agreed to be filmed and interviewed by the NBC morning news show because University Hospitals is the first — and so far only — hospital to use the C7-XR Imaging System and accompanying C7 Dragonfly Imaging Catheter made by LightLab Imaging Inc. during patient heart procedures.

While using the technology to place a stent in one of Bailey’s heart arteries, Costa found a second blocked artery that had not shown up on images of Bailey’s heart. Costa ended up placing two stents, that day.

“If he had gone home this weekend without having this procedure today, he would have gone home with a very nice, well-placed stent in the vessel that did not cause the heart attack,” Costa said during the Good Morning America segment.

The LightLab system uses near-infrared light to produce high-resolution, real-time images that are better and faster than images produced by competing ultrasound technology. The system recently was approved for sale by the Food and Drug Administration. UH Case Medical Center was the core laboratory on the FDA approval study and analyzed the study’s results, according to the Case Western Reserve University School of Medicine blog.

Impotence plus heart disease ups death risk – Dr. Sahil Parikh discusses the study

May 27, 2010

Reuters Report ::

Men with heart disease who also have erectile dysfunction die sooner than men who do not seek treatment for impotence, researchers reported on Monday.

They found that men who had both conditions were twice as likely to die from any cause and twice as likely to have a heart attack than men with heart disease alone.

The researchers expressed concern that using drugs such as Pfizer’s Viagra or Eli Lilly’s Cialis to treat erectile dysfunction could mask the symptoms that point to widespread heart and artery disease and said men complaining of impotence should be checked by a cardiologist.

“Erectile dysfunction is something that regularly should be addressed in the medical history of patients; it might be a symptom of early atherosclerosis,” Dr. Michael Bohm of the University of Saarland in Germany, who led the study, said in a statement.

His team studied 1,519 men in 13 countries taking part in some larger studies of various heart disease treatments. As part of the study the men were also asked about erectile dysfunction.

More than half of them, 55 percent, did, Bohm’s team said in a report published in the journal Circulation and also presented at a meeting of the American College of Cardiology.

During the two years of the study, 11.3 percent of the patients who reported erectile dysfunction died, compared to 5.6 percent of those with mild or no impotence problems.

“It has long been known that erectile dysfunction is a marker for cardiovascular disease,” said Dr. Sahil Parikh at University Hospitals Case Medical Center in Cleveland, Ohio, who was not involved in the study.

The first impotence drug, Pfizer’s Viagra, known generically as sildenafil, was at first developed to lower blood pressure, he said.

“They realized it had this other effect, which patients quite enjoyed,” Parikh said in a telephone interview.

HAPPY SIDE-EFFECT

Viagra and rival drugs such as Eli Lilly’s Cialis and Bayer AG’s BAYG.DE Levitra all work by increasing blood flow.

“In order to have proper erectile function, you have to have adequate blood flow to the genitals. If you have atherosclerosis, whether in the arteries on the neck, which can cause stroke, or the arteries of the heart, which can cause heart attack … it is the same disease.”

But while the erectile dysfunction drugs help blood flow all over the body, they do not treat the underlying hardening and narrowing in the arteries that is causing the problem.

“If patients have erectile dysfunction, we have to be very aggressive about screening and treating them for heart disease,” Parikh said.

When Viagra came onto the market, many health experts welcomed it as a way to get men who might otherwise neglect their health to go to a doctor. But Bohm and Parikh both agreed that patients — and their doctors — need to look hard at the hearts of men with erectile dysfunction.

“Men with ED going to a general practitioner or a urologist need to be referred for a cardiology workup to determine existing cardiovascular disease and proper treatment,” Bohm said.

“The medication works and the patient doesn’t show up any more,” he added. “These men are being treated for the ED, but not the underlying cardiovascular disease.”

The drugs are wildly popular. Viagra alone had sales of nearly $2 billion in 2009.

Donald Hricik discusses new hypertension study published in the Journal of American Medical Association

May 27, 2010

Half of Americans are in control of their blood pressure. But the number of new cases has gone up according to a new study out published in the Journal of American Medical Association which finds that one out of every three people had their hypertension under control 20 years ago compared to 50% of patients now. However, the number of people diagnosed with the condition has continued to go up.

Dr. Donald Hricik of CWRUmedicine Division of Nephrology and Hypertension at University Hospitals Case Medical Center is interviewed for the story. Watch the video.

Katie Couric Tours Case Western Reserve Research Lab

May 19, 2010

Katie Couric visited Sanford “Sandy” Markowitz, MD, PhD, professor and researcher of cancer and genetics, and his research team in his lab to gain a better understanding of the day-to-day research necessary for advancements in colon cancer.

The CBS Evening News with Katie Couric anchor and managing editor received a warm welcome from the researchers, who provided Couric with hands-on training. They also informed her of the various research projects being conducted in the Markowitz lab at Case Western Reserve University Department of Medicine.

The touching visit brought together Couric and Markowitz, who have been working together for years to improve colon cancer screening, and ultimately the disease. Couric’s late husband, Jay Monahan, succumbed to the disease in 1998.

Couric went on to help co-found The Entertainment Industry Foundation’s National Colorectal Cancer Research Alliance, which has raised awareness and funding for colon cancer research.

Learn more at CWRUmedicine.org

MORE about our RESEARCH

April 26, 2010

MORE about our RESEARCH

The Case Western Reserve University Department of Medicine has contributed several historical breakthroughs in the fields of medicine and health. Indeed, the CWRU School of Medicine boasts eight Nobel laureates among its faculty and alumni, including former professor of physiology John J.R. Macleod, who was awarded the Nobel Prize for Physiology and Medicine in 1923 for the discovery of insulin, and alumnus Paul C. Lauterbur, B.S. Chemistry ’51, who shared the Nobel Prize for Physiology and Medicine in 2003 with Sir Peter Mansfield for discoveries in magnetic resonance imaging. Other notable research accomplishments by School faculty are the first surgical treatments of coronary artery disease, the first simulated milk formula for infants, development of the first heart-lung machine for use in open heart surgeries, the first successful genetic alteration of human cells in a test tube and creation of the first artificial human chromosome.

Today, research being conducted by faculty and students at the Department of Medicine ranges from examining infectious diseases of the developing world to creating the first stool test that detects colon cancer, and much more. Of additional note, the School of Medicine was awarded $64 million from the National Science Foundation to form the Clinical and Translational Science Collaborative in partnership with three hospital affiliates.

The Case Western Reserve University Department of Medicine is affiliated with some of the best hospitals in the United States and is committed to developing a research portfolio that is aligned with their strategic clinical initiatives. Department affiliates include University Hospitals Case Medical Center, Cleveland Clinic, The MetroHealth System and Louis Stokes Cleveland Department of Veterans Affairs Medical Center.

Through these partnerships, several cutting-edge technologies and research facilities are available to faculty and students. Core facilities of the School are the Case Medical Center, which comprises Case Western Reserve University and University Hospitals Health System, the Cleveland Clinic Lerner Research Institute, and the MetroHealth Medical System Rammelkamp Center for Education and Research. Additional prominent facilities include the Case Center for Imaging Research, Case Comprehensive Cancer Center, Center for Aids Research, National Prion Disease Pathology Surveillance Center (the only one of its kind in the United States), Center for Proteomics and Bioinformatics, and Center for Global Health and Disease.

To maintain such a high standard of biomedical research, the Department of Medicine continually looks to the future.

Learn more at CWRUmedicine.org