Posts Tagged ‘case western reserve department of medicine’

Research Day :: Photo Gallery

June 2, 2010

Research Day :: May 7, 2010

Congratulations to everyone who participated in the Department of Medicine 2010 Research Day. The event had a tremendous turnout of faculty and young investigators. We are very proud of the research you are producing.

Check out the pictures from this CWRUmedicine event …



April 26, 2010


The Case Western Reserve University Department of Medicine has contributed several historical breakthroughs in the fields of medicine and health. Indeed, the CWRU School of Medicine boasts eight Nobel laureates among its faculty and alumni, including former professor of physiology John J.R. Macleod, who was awarded the Nobel Prize for Physiology and Medicine in 1923 for the discovery of insulin, and alumnus Paul C. Lauterbur, B.S. Chemistry ’51, who shared the Nobel Prize for Physiology and Medicine in 2003 with Sir Peter Mansfield for discoveries in magnetic resonance imaging. Other notable research accomplishments by School faculty are the first surgical treatments of coronary artery disease, the first simulated milk formula for infants, development of the first heart-lung machine for use in open heart surgeries, the first successful genetic alteration of human cells in a test tube and creation of the first artificial human chromosome.

Today, research being conducted by faculty and students at the Department of Medicine ranges from examining infectious diseases of the developing world to creating the first stool test that detects colon cancer, and much more. Of additional note, the School of Medicine was awarded $64 million from the National Science Foundation to form the Clinical and Translational Science Collaborative in partnership with three hospital affiliates.

The Case Western Reserve University Department of Medicine is affiliated with some of the best hospitals in the United States and is committed to developing a research portfolio that is aligned with their strategic clinical initiatives. Department affiliates include University Hospitals Case Medical Center, Cleveland Clinic, The MetroHealth System and Louis Stokes Cleveland Department of Veterans Affairs Medical Center.

Through these partnerships, several cutting-edge technologies and research facilities are available to faculty and students. Core facilities of the School are the Case Medical Center, which comprises Case Western Reserve University and University Hospitals Health System, the Cleveland Clinic Lerner Research Institute, and the MetroHealth Medical System Rammelkamp Center for Education and Research. Additional prominent facilities include the Case Center for Imaging Research, Case Comprehensive Cancer Center, Center for Aids Research, National Prion Disease Pathology Surveillance Center (the only one of its kind in the United States), Center for Proteomics and Bioinformatics, and Center for Global Health and Disease.

To maintain such a high standard of biomedical research, the Department of Medicine continually looks to the future.

Learn more at

Susan Redline discusses Sleep Apnea Increases Stroke Risk with WebMD

April 9, 2010

Moderate to Severe Sleep Apnea Triples Stroke Risk in Men, Study Finds

WebMD | April 8, 2010

Obstructive sleep apnea more than doubles the risk of stroke in men and also increases the danger in women, new research indicates.

The finding comes from a major study of 5,422 people aged 40 and older who had no history of stroke. Researchers say increased risk of stroke appeared in men with mild sleep apnea and rose with severity.

Men with moderate to severe sleep apnea were about three times more likely to have a stroke than men with mild or no sleep apnea, researchers say.

The increased risk of stroke in women with obstructive sleep apnea was significant only in cases of severe apnea, according to the study, published in the American Journal of Respiratory and Critical Care Medicine.

Obstructive Sleep Apnea and Stroke

Data were taken from the Sleep Heart Health Study, which is ongoing at a number of locations. The participants in the beginning performed a standard at-home sleep test to determine whether they had sleep apnea, and if so, its severity.

They were followed for about nine years, and during that time, 193 suffered strokes — 85 men out of 2,462 enrolled and 108 women out of 2,960.

“Although more women had strokes, relatively more men with sleep apnea than without sleep apnea had strokes, and less so in women,” study author Susan Redline, MD, MPH, of Case Western Reserve University in Cleveland, tells WebMD in an email. “I think that the relatively greater impact of sleep apnea on risk of stroke in men relates to the likely longer duration of sleep apnea in men than women.”

Researchers say more than 15 million strokes occur worldwide every year, and that about a third are fatal. Increased risk of stroke in people with sleep apnea exists even without other risk factors, such as weight, high blood pressure, race, diabetes, and smoking.

Men may be more at risk because they develop sleep apnea at younger ages, the researchers say, and thus go untreated for longer periods.

Learn more at

CWRUmedicine and UH develops New Drugs to improve oxygen delivery to tissues

April 8, 2010

Case Western Reserve University and University Hospitals are pleased to announce the awarding of a $4.7 million contract from the Defense Advanced Research Projects Agency (DARPA) to Dr. Jonathan Stamler, Director of the Institute for Transformative Molecular Medicine (ITMM).

The grant will fund development of a new class of drugs that selectively vasodilate under hypoxia and thereby enhance performance at high altitude (e.g. soldiers on mountains in Afganistan).

It is also anticipated that the grant will generate new physiologic information on high-altitude adaptation and new therapeutic interventions to treat patients suffering from conditions where oxygen delivery is impaired, including heart failure, ischemic heart disease, stroke, sickle cell disease and diabetes.

Studies will involve a transdisciplinary approach, including the Department of Anesthesia (James Reynolds) the division of Pulmonary Medicine (Kingman Stroh), and the Harrington-McLaughlin Cardiovascular Institute (Sahil Parikh).

Learn more at

Armand Krikorian, MD publishes “Comparisons of Different Insulin Infusion Protocols”

April 7, 2010

“Comparisons of different insulin infusion protocols: a review of recent literature”

Curr Opin Clin Nutr Metab Care. 2010 March
Krikorian A, Ismail-Beigi F, Moghissi ES.

Division of Clinical & Molecular Endocrinology
Case Western Reserve University
University Hospitals, Cleveland

Read the abstract at

Mitochondrial dynamics in Alzheimer’s disease

April 7, 2010

“Mitochondrial dynamics in Alzheimer’s disease: opportunities for future treatment strategies”

Drugs Aging. 2010 Mar 1

Bonda DJ, Wang X, Perry G, Smith MA, Zhu X.
Department of Pathology, Case Western Reserve University, Cleveland


Journal of Lipid Research publish Dr Charles Hoppels recent work on the inner mitochondrial membrane

April 7, 2010

“Separation and characterization of cardiolipin molecular species by reverse-phase ion pair high-performance liquid chromatography-mass spectrometry”

J Lipid Res. 2010 Apr
Minkler PE, Hoppel CL.

Center for Mitochondrial Diseases, Division of Pharmacology, Department of Medicine, Case Medical Center, University Hospitals, Cleveland

Read the full abstract on