Posts Tagged ‘cwru school of medicine’

CWRU School of Medicine :: Medical Firsts

June 25, 2010

* 1905 Development of the modern technique for human blood transfusion using a cannula to connect blood vessels by surgeon George Crile
* 1912 Pioneering the process of chlorinating drinking water by Professor Roger Perkins
* 1915 First simulated milk formula for infants, by alumnus and pediatrics professor Henry Gerstenberger
* 1927 Discovery of the cause of ptomaine food poisoning and development of an antiserum by immunologist Enrique Ecker and colleagues

* 1935 First surgical treatment of coronary artery disease by Professor Claude Beck

* 1950s Development of the first heart-lung machine for use in open heart surgeries by Professor Frederick Cross
* 1961 First successful genetic alteration of human cells in a test tube by Professor Austin Weisburger
* 1969 William Insull, M.D., describes the role of cholesterol in blood vessel disease
* 1975 Discovery that human rennin, an enzyme produced by the kidney, is involved in hypertension
* 1990 Discovery of the gene for osteoarthritis by a national team led by rheumatologist Roland Moskowitz
* 1991 First triple organ transplant in Ohio-a kidney, liver and pancreas-by James A. Schulak, M.D., and colleagues
* 1997 Creation of the world’s first artificial human chromosome by a team led by Professor Huntington Willard

Additional medical firsts include:

* First large-scale medical research project on humans in a study linking iodine with goiter prevention
* Discovery of early treatment of strep throat infections to prevent rheumatic fever
* Discovery of the Hageman factor in blood clotting, a major discovery in blood coagulation research
* First description of how staphylococcus infections were transmitted, leading to required hand-washing between patients in infant nurseries
* First description of what was later named Reye’s syndrome
* Research leading to FDA approval of clozapine, the most advanced treatment for schizophrenia at the time


CWRU School of Medicine :: Historical Highlights

June 25, 2010

* In 1843, five faculty members and sixty-seven students began the first medical lectures at the Medical Department of Western Reserve College (also known as the Cleveland Medical College).
* In 1852, the medical school became the second allopathic medical school to graduate a woman, Nancy Talbot Clarke.
* Six of the first seven women in the United States to receive medical degrees from recognized allopathic medical schools graduated from Western Reserve University (as it was called then) between 1850 and 1856.
* The School of Medicine was one of the first in the country to employ instructors devoted to full-time teaching and research.
* In 1896, the first affiliation agreement was approved between Western Reserve University and University Hospitals of Cleveland (Lakeside Hospital).
* The Western Reserve University School of Medicine revolutionized medical education in 1952 with the most progressive curriculum in the country which integrated the basic and clinical sciences.
* In 2002, the School of Medicine became only the third medical school in history to receive the best review possible from the Liaison Committee on National Education, the national body responsible for accrediting the medical schools.
* In 2006, the School of Medicine’s University Program instituted a new integrated curriculum of medicine and public health awareness, which emphasizes the both the biology of disease and social and behavioral context of illness.

CWRU School of Medicine FACTS & FIGURES

June 25, 2010

Student Body

* More than 5,700 applications were received by the School of Medicine for the 2008-2009 year.
* For the 2007-2008 year, the School of Medicine had 1,475 full-time and part-time students with 698 in M.D. degree programs and 777 in M.S./Ph.D. programs.
* Of approximately 140 graduates each year, 96 percent pass Step 1 and 97 percent pass Step 2 of the United States Medical Licensing Examination.

Faculty and Research

* The School of Medicine has more than 3,800 faculty members.
* There are 620 full-time faculty members working on National Institute of Health research grants and 595 NIH-funded studies.
* The total NIH annual research funds granted to the School of Medicine in 2008 was $243,512,609.

Programs and Departments

* The School of Medicine offers 25 graduate degree options, including M.D., dual M.D./Ph.D. degrees and combined M.S./Ph.D. programs.
* The School of Medicine has 54 academic departments and 28 research centers and institutes.


* The School of Medicine is ranked as one of the nation’s top 20 medical schools by U.S. News & World Report’s Guide to Graduate Education. Additionally, the Departments of Family Medicine and Pediatrics are ranked 13th in the country.
* The largest medical research institution in Ohio, the School of Medicine at Case Western Reserve University was ranked 15th highest in research funding by the National Institutes of Health in 2007.
* During 2007, the economic impact of the School of Medicine and its affiliates on the State of Ohio equaled $5.82 billion and accounted for more than 65,000 Ohio jobs.

Ohio Senate grants letter of commendation to School of Medicine

June 8, 2010

The members of the Senate of the 128th General Assembly of Ohio paid tribute the School of Medicine in an official letter of commendation for being ranked as the 20th best medical school in research in the nation, as ranked by U.S. News & World Report.

The letter praised our institution, “known for its dedication to medical research, and the world of its highly qualified and committed staff has earned the university an exceptional reputation.”

Signed by Senator Bill Harris, President of the Ohio Senate, and Senator Shirley A. Smith, Assistant Minority Leader, the acknowledgement applauds the School’s innumerable contributions to the study of medicine.

CWRUmedicine Annual Research Day

April 13, 2010

CWRUmedicine Annual Research DayResearch Day provides an opportunity for researchers in training at the Case Western Reserve University Department of Medicine to present their biomedical research in a public forum.

This group includes trainees at all levels of programming, including graduate, undergraduate, medical and MD/PhD students, as well as postdoctoral fellows and researchers and clinical residents and fellows.

Research Day also presents an opportunity for colleagues and visitors to learn about the cutting edge research occuring at Case Medical Center.

With multiple posters representing a wide array of research topics are displayed throughout the day, with presenters on hand to discuss their projects and research findings with visitors and guests.

Learn more at

Susan Redline discusses Sleep Apnea Increases Stroke Risk with WebMD

April 9, 2010

Moderate to Severe Sleep Apnea Triples Stroke Risk in Men, Study Finds

WebMD | April 8, 2010

Obstructive sleep apnea more than doubles the risk of stroke in men and also increases the danger in women, new research indicates.

The finding comes from a major study of 5,422 people aged 40 and older who had no history of stroke. Researchers say increased risk of stroke appeared in men with mild sleep apnea and rose with severity.

Men with moderate to severe sleep apnea were about three times more likely to have a stroke than men with mild or no sleep apnea, researchers say.

The increased risk of stroke in women with obstructive sleep apnea was significant only in cases of severe apnea, according to the study, published in the American Journal of Respiratory and Critical Care Medicine.

Obstructive Sleep Apnea and Stroke

Data were taken from the Sleep Heart Health Study, which is ongoing at a number of locations. The participants in the beginning performed a standard at-home sleep test to determine whether they had sleep apnea, and if so, its severity.

They were followed for about nine years, and during that time, 193 suffered strokes — 85 men out of 2,462 enrolled and 108 women out of 2,960.

“Although more women had strokes, relatively more men with sleep apnea than without sleep apnea had strokes, and less so in women,” study author Susan Redline, MD, MPH, of Case Western Reserve University in Cleveland, tells WebMD in an email. “I think that the relatively greater impact of sleep apnea on risk of stroke in men relates to the likely longer duration of sleep apnea in men than women.”

Researchers say more than 15 million strokes occur worldwide every year, and that about a third are fatal. Increased risk of stroke in people with sleep apnea exists even without other risk factors, such as weight, high blood pressure, race, diabetes, and smoking.

Men may be more at risk because they develop sleep apnea at younger ages, the researchers say, and thus go untreated for longer periods.

Learn more at

CWRUmedicine and UH develops New Drugs to improve oxygen delivery to tissues

April 8, 2010

Case Western Reserve University and University Hospitals are pleased to announce the awarding of a $4.7 million contract from the Defense Advanced Research Projects Agency (DARPA) to Dr. Jonathan Stamler, Director of the Institute for Transformative Molecular Medicine (ITMM).

The grant will fund development of a new class of drugs that selectively vasodilate under hypoxia and thereby enhance performance at high altitude (e.g. soldiers on mountains in Afganistan).

It is also anticipated that the grant will generate new physiologic information on high-altitude adaptation and new therapeutic interventions to treat patients suffering from conditions where oxygen delivery is impaired, including heart failure, ischemic heart disease, stroke, sickle cell disease and diabetes.

Studies will involve a transdisciplinary approach, including the Department of Anesthesia (James Reynolds) the division of Pulmonary Medicine (Kingman Stroh), and the Harrington-McLaughlin Cardiovascular Institute (Sahil Parikh).

Learn more at

New Research from the Division of Infectious Disease on Beta-Lactamases

April 7, 2010

Penicillin sulfone inhibitors of class D beta-lactamases
Antimicrob Agents Chemother. 2010 Apr

Drawz SM, Bethel CR, Doppalapudi VR,Hujer AM, Skalweit MJ, Anderson VE, Chen SG, Buynak JD, Bonomo RA.
Departments of Pathology, Case Western Reserve School of Medicine, Cleveland

Armand Krikorian, MD publishes “Comparisons of Different Insulin Infusion Protocols”

April 7, 2010

“Comparisons of different insulin infusion protocols: a review of recent literature”

Curr Opin Clin Nutr Metab Care. 2010 March
Krikorian A, Ismail-Beigi F, Moghissi ES.

Division of Clinical & Molecular Endocrinology
Case Western Reserve University
University Hospitals, Cleveland

Read the abstract at