Posts Tagged ‘cwrumedicine research’

MORE about our RESEARCH

April 26, 2010

MORE about our RESEARCH

The Case Western Reserve University Department of Medicine has contributed several historical breakthroughs in the fields of medicine and health. Indeed, the CWRU School of Medicine boasts eight Nobel laureates among its faculty and alumni, including former professor of physiology John J.R. Macleod, who was awarded the Nobel Prize for Physiology and Medicine in 1923 for the discovery of insulin, and alumnus Paul C. Lauterbur, B.S. Chemistry ’51, who shared the Nobel Prize for Physiology and Medicine in 2003 with Sir Peter Mansfield for discoveries in magnetic resonance imaging. Other notable research accomplishments by School faculty are the first surgical treatments of coronary artery disease, the first simulated milk formula for infants, development of the first heart-lung machine for use in open heart surgeries, the first successful genetic alteration of human cells in a test tube and creation of the first artificial human chromosome.

Today, research being conducted by faculty and students at the Department of Medicine ranges from examining infectious diseases of the developing world to creating the first stool test that detects colon cancer, and much more. Of additional note, the School of Medicine was awarded $64 million from the National Science Foundation to form the Clinical and Translational Science Collaborative in partnership with three hospital affiliates.

The Case Western Reserve University Department of Medicine is affiliated with some of the best hospitals in the United States and is committed to developing a research portfolio that is aligned with their strategic clinical initiatives. Department affiliates include University Hospitals Case Medical Center, Cleveland Clinic, The MetroHealth System and Louis Stokes Cleveland Department of Veterans Affairs Medical Center.

Through these partnerships, several cutting-edge technologies and research facilities are available to faculty and students. Core facilities of the School are the Case Medical Center, which comprises Case Western Reserve University and University Hospitals Health System, the Cleveland Clinic Lerner Research Institute, and the MetroHealth Medical System Rammelkamp Center for Education and Research. Additional prominent facilities include the Case Center for Imaging Research, Case Comprehensive Cancer Center, Center for Aids Research, National Prion Disease Pathology Surveillance Center (the only one of its kind in the United States), Center for Proteomics and Bioinformatics, and Center for Global Health and Disease.

To maintain such a high standard of biomedical research, the Department of Medicine continually looks to the future.

Learn more at CWRUmedicine.org

CWRUmedicine and UH develops New Drugs to improve oxygen delivery to tissues

April 8, 2010

Case Western Reserve University and University Hospitals are pleased to announce the awarding of a $4.7 million contract from the Defense Advanced Research Projects Agency (DARPA) to Dr. Jonathan Stamler, Director of the Institute for Transformative Molecular Medicine (ITMM).

The grant will fund development of a new class of drugs that selectively vasodilate under hypoxia and thereby enhance performance at high altitude (e.g. soldiers on mountains in Afganistan).

It is also anticipated that the grant will generate new physiologic information on high-altitude adaptation and new therapeutic interventions to treat patients suffering from conditions where oxygen delivery is impaired, including heart failure, ischemic heart disease, stroke, sickle cell disease and diabetes.

Studies will involve a transdisciplinary approach, including the Department of Anesthesia (James Reynolds) the division of Pulmonary Medicine (Kingman Stroh), and the Harrington-McLaughlin Cardiovascular Institute (Sahil Parikh).

Learn more at CWRUmedicine.org

Mitochondrial dynamics in Alzheimer’s disease

April 7, 2010

“Mitochondrial dynamics in Alzheimer’s disease: opportunities for future treatment strategies”

Drugs Aging. 2010 Mar 1

Bonda DJ, Wang X, Perry G, Smith MA, Zhu X.
Department of Pathology, Case Western Reserve University, Cleveland

Read more at CWRUmedicine.org