Posts Tagged ‘Infectious Diseases’

New Research from the Division of Infectious Disease on Beta-Lactamases

April 7, 2010

Penicillin sulfone inhibitors of class D beta-lactamases
Antimicrob Agents Chemother. 2010 Apr

Drawz SM, Bethel CR, Doppalapudi VR,Hujer AM, Skalweit MJ, Anderson VE, Chen SG, Buynak JD, Bonomo RA.
Departments of Pathology, Case Western Reserve School of Medicine, Cleveland

Dr. Louis Rice discusses the rise of unstoppable germs

March 10, 2010

Drug options are dwindling for doctors to treat certain types of infection.

The biggest challenges come from evolution, science and economic factors that hinder the technology behind drug development.

Dr. Louis Rice, Chief of the medical service at the Louis Stokes Cleveland VA Medical Center and professor at Case Western Reserve University discusses the growing threat of antibiotics.

Listen to the podcast at CWRUmedicine.org

NY Times :: ID expert, Dr Louis Rice, discusses Rising Threat of Infections Unfazed by Antibiotics

February 28, 2010

A minor-league pitcher in his younger days, Richard Armbruster kept playing baseball recreationally into his 70s, until his right hip started bothering him. Last February he went to a St. Louis hospital for what was to be a routine hip replacement.

By late March, Mr. Armbruster, then 78, was dead. After a series of postsurgical complications, the final blow was a bloodstream infection that sent him into shock and resisted treatment with antibiotics.

“Never in my wildest dreams did I think my dad would walk in for a hip replacement and be dead two months later,” said Amy Fix, one of his daughters.

Not until the day Mr. Armbruster died did a laboratory culture identify the organism that had infected him: Acinetobacter baumannii.

The germ is one of a category of bacteria that by some estimates are already killing tens of thousands of hospital patients each year. While the organisms do not receive as much attention as the one known as MRSA — for methicillin-resistant Staphylococcus aureus — some infectious-disease specialists say they could emerge as a bigger threat.

That is because there are several drugs, including some approved in the last few years, that can treat MRSA. But for a combination of business reasons and scientific challenges, the pharmaceuticals industry is pursuing very few drugs for Acinetobacter and other organisms of its type, known as Gram-negative bacteria. Meanwhile, the germs are evolving and becoming ever more immune to existing antibiotics.

In many respects it’s far worse than MRSA,” said Dr. Louis B. Rice, an infectious-disease specialist at the Louis Stokes Cleveland V.A. Medical Center and at Case Western Reserve University. “There are strains out there, and they are becoming more and more common, that are resistant to virtually every antibiotic we have.”

Read more at CWRUmedicine.org

Infectious Diseases member, Michael Lederman, elected to the American Academy of Microbiology

February 24, 2010

Seventy-eight microbiologists have been elected to Fellowship in the American Academy of Microbiology. Fellows of the Academy are elected annually through a highly selective, peer-review process, based on their records of scientific achievement and original contributions that have advanced microbiology. Michael M. Lederman, M.D., Case Western Reserve University School of Medicine, University Hospitals of Cleveland, was chosen to join the elite group of 78 members.

Read more on PhysOrg.com

Congratulations to the Department of Medicine doctors who have been awarded the “Best Doctors” title by their peers.

February 24, 2010

The Department of Medicine would like to congratulate our doctors who have been recognised in Cleveland Magazine’s “Best Doctors” list.

We want to thank the entire community of CWRUmedicine physicians, nurses and staff for the work they do every day.

2010-bestdocsCardiovascular Medicine
Dr. Mauricio S. Arruda
Dr. John Blebea
Dr. Barry A. Effron
Dr. James Fang
Dr. Michel George Farah
Dr. Steven A. Fisher
Dr. Robert Goldstein
Dr. Austin A. Halle IIIte
Dr. Brian Hoit
Dr. Richard A. Josephson
Dr. Joseph I. Krall
Dr. Judith Mackall
Dr. Sri Krishna Madan Mohan
Dr. Carl E. Orringer
Dr. Aaron Proweller
Dr. Daniel I. Simon
Dr. Bruce S. Stambler
Dr. Albert L. Waldo

Clinical and Molecular Endocrinology
Dr. Baha Mahmoud Arafah

Gastroenterology and Liver Disease
Dr. Amitabh Chak
Dr. Fabio Cominelli
Dr. Gregory S. Cooper
Dr. Ashley L. Faulx
Dr. Gerard Isenberg
Dr. Jeffry A. Katz

Oncology and Hematology
Dr. Matthew M. Cooney
Dr. Brenda W. Cooper
Dr. Afshin Dowlati
Dr. Stanton L. Gerson
Dr. Joseph Gibbons
Dr. Smitha Subramanyan Krishnamurthi
Dr. Hillard Michael Lazarus
Dr. Nathan Levitan
Dr. Neal J. Meropol
Dr. Paula Silverman

Infectious Disease & HIV
Dr. Keith B. Armitage
Dr. Barbara M. Gripshover
Dr. Michael M. Lederman
Dr. Robert A. Salata

Nephrology & Hypertension
Dr. Donald E. Hricik
Dr. Daniel B. Ornt
Dr. Michael C. Smith

Pulmonary, Critical Care & Sleep
Dr. Rana B. Hejal
Dr. Hugo Montenegro
Dr. Robert John Schilz
Dr. Kingman P. Strohl